Regulation of angiogenesis in diabetic retinopathy: possible balance between vascular endothelial growth factor and endostatin
H Noma, H Funatsu, H Yamashita… - Archives of …, 2002 - jamanetwork.com
Objective To investigate the mechanisms of regulation between vascular endothelial growth
factor (VEGF) as a stimulator and endostatin as an inhibitor of angiogenesis in diabetic
retinopathy (DR). Methods One hundred fifty-nine eyes of 120 diabetic patients were
studied. Concentrations of VEGF and endostatin in vitreous fluid and aqueous humor,
obtained from the eyes during ocular surgery, were measured by enzyme-linked
immunosorbent assay. The severity of DR was quantified according to the Early Treatment …
factor (VEGF) as a stimulator and endostatin as an inhibitor of angiogenesis in diabetic
retinopathy (DR). Methods One hundred fifty-nine eyes of 120 diabetic patients were
studied. Concentrations of VEGF and endostatin in vitreous fluid and aqueous humor,
obtained from the eyes during ocular surgery, were measured by enzyme-linked
immunosorbent assay. The severity of DR was quantified according to the Early Treatment …
